- Amelia Street Historic District [ Orangeburg City ]
- Ballards Pointe [ Santee Town ]
- Belmont Plantation [ Eutawville Town ]
- Belvedere [ Eutawville Town ]
- Blackwater [ Elloree Town ]
- Bradford Village [ Santee Town ]
- Calhoun [ Elloree Town ]
- Carolina Terrace [ Orangeburg City ]
- Chapel Creek Plantation [ Santee Town ]
- Claflin College Historic District [ Orangeburg City ]
- Downtown Historic District [ Orangeburg City ]
- Downtown Historic District [ Holly Hill Town ]
- Eagle Landing [ Elloree Town ]
- East Russell Street Historic District [ Orangeburg City ]
- Ellis Avenue Historic District [ Orangeburg City ]
- Eutaw Heights [ Eutawville Town ]
- Eutawville Springs [ Eutawville Town ]
- Fountain Lake [ Eutawville Town ]
- Green Acres [ Orangeburg City ]
- Green Bluff [ Santee Town ]
- High Hill [ Santee Town ]
- Holly Acres [ Holly Hill Town ]
- Johns Gate [ Holly Hill Town ]
- Lakewilde Plantation [ Elloree Town ]
- Marshall Heights [ Orangeburg City ]
- Pinckneys Mill [ Santee Town ]
- Quail Hollow [ Elloree Town ]
- Rocks Pond Estates [ Eutawville Town ]
- Santee Cooper Resort [ Santee Town ]
- Satawen [ Eutawville Town ]
- Smithfield [ Holly Hill Town ]
- South Carolina State College Historic District [ Orangeburg City ]
- St Julien [ Vance Town ]
- Treadwell Street Historic District [ Orangeburg City ]
- Wampee Plantation [ Eutawville Town ]
- Whitman Street Area Historic District [ Orangeburg City ]
- Wilkinson Hieghts [ Orangeburg City ]